Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients

Acute Renal Failure Clinical Trial

— CONVINT  

Official title:

Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01228123
• Other study ID #: CONVINT
• Status: Completed
• Phase: Phase 2/Phase 3
• First received: October 25, 2010
• Last updated: May 23, 2011
• Start date: January 2002
• Est. completion date: January 2008

Study information

• Verified date: July 2010
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Federal Institute for Drugs and Medical Devices
• Study type: Interventional

Clinical Trial Summary

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Description:

please see above

Recruitment information / eligibility

• Status: Completed
• Enrollment: 252
• Est. completion date: January 2008
• Est. primary completion date: October 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• all ICU patients requiring renal replacement therapy

Exclusion Criteria:

• patient denies informed consent

• patient not requiring intensive care therapy

• kidney transplanted patients

• chronic renal failure (serum creatinine > 3mg/dl)

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Renal Failure
• Renal Insufficiency

Intervention

Other:
• RRT for acute kidney failure using the CVVH method
patients randomized to receive CVVH
• RRT for acute kidney failure using the IHD (intermittent HD)
patients randomized to receive IHD

Locations

Country	Name	City	State
Germany	Charite University Medicine	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Survival at 2 weeks after RRT		2 weeks after RRT in follow-up	No