Acute Promyelocytic Leukemia Clinical Trial
Official title:
The French Registry on the First-line Treatment of Non High-risk Acute Promyelocytic Leukemia (APL) in Patients Aged ≤ 70 Years
The registry aims to compare the two first-line available treatment approaches in non-high-risk APL patients aged ≤ 70 years - ATRA plus chemotherapy and ATRA plus ATO - in terms of practitioner's choice between the two options, clinical effectiveness and cost-effectiveness, long-term outcome, and short- and long-term toxic effects.
- Collection of epidemiological data on non-high-risk APL patients aged ≤ 70 years: age
and sex distribution, medical history, prognostic factors (time to treatment start,
severity of coagulopathy at presentation, Performance status…).
- Documentation of clinical and biologic effectiveness of the two first-line treatment
approaches available for non-high-risk APL patients.
- Documentation of Minimal Residual Disease (MRD).
- Correlation of clinical outcomes with the chosen therapy.
- Validation of published prognostic factors and identification of new prognostic factors
;
Observational Model: Case Control, Time Perspective: Prospective
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