Prevalence of Echocardioghraphic and ECG Changes in Patients With Acute Pancreatitis and Its Impact on Outcome.

Acute Pancreatitis Clinical Trial

Official title:

Prevalence of Echocardioghraphic and ECG Changes in Patients With Acute Pancreatitis and Its Impact on Outcome.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04196504
• Other study ID #: Echo_ECG_pancreatitis
• Status: Not yet recruiting
• Start date: December 31, 2019
• Est. completion date: December 31, 2021

Study information

• Verified date: December 2019
• Source: Assiut University
• Contact: Alaaeldin M. Abdelrahman, MBBS
• Phone: 01144780935
• Email: aladdinmahmoud[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Cardiovascular system involvement with acute pancreatitis has been described before in the form of ECG changes and echocardiographic findings. However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.

Description:

Acute pancreatitis is a relatively common disease with significant morbidity and mortality. About 75% of pancreatitis is caused by gallstones or alcohol. The Atlanta classification of acute pancreatitis has been used to differentiate between severe and mild cases of acute pancreatitis. According to this classification, patients are diagnosed with severe acute pancreatitis if they show evidence of organ failure, Local complications (eg, necrosis, abscess, pseudocyst), Ranson score of 3 or higher or APACHE score of 8 or higher. Severe acute pancreatitis has a wide range of affection on nearly all body systems with various degrees of affection than affect both the clinical picture and the prognosis of the disease. the cardiovascular system involvement has been described before ,in the form of ECG changes (sinus tachycardia, arrhythmias, conduction abnormalities.. ) and echocardiographic findings (diastolic,systolic or combined dysfunction, wall motion abnormalities, pericardial effusion..). However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. completion date: December 31, 2021
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• all patients with acute pancreatitis aged more than 18 yrs admitted to Al-raghy ICU of all etiologies

Exclusion Criteria:

• patients less that 18 years

• patients above 80 years

• patients with known cardiac disease

• patients with pre-existing diabetes, chronic renal failure or malignancy.

• patients with underlying chronic pancreatitis

Related Conditions & MeSH terms

• Acute Pancreatitis
• Pancreatitis

Intervention

Device:
• Echocardiograghy, ECG
transthoracic echocariography, 12 lead ECG

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Echocardiographic (mainly diastolic dysfunction & pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.	To detect the echocardiographic (mainly diastolic dysfunction & pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.	at admission on 1st day
Primary	determine the impact of these changes on outcome of patients	determine the impact of these changes on outcome of patients	though out hospital admission (an average of 1 week)