Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis

Acute Pancreatitis Clinical Trial

Official title:

Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity and Clinical Outcomes of Severe Acute Pancreatitis

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03282253
• Other study ID #: ESCDEPDSSAP
• Status: Not yet recruiting
• Phase: N/A
• First received: September 12, 2017
• Last updated: November 23, 2017
• Start date: January 1, 2018
• Est. completion date: June 30, 2019

Study information

• Verified date: November 2017
• Source: Nanjing University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 216
• Est. completion date: June 30, 2019
• Est. primary completion date: December 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission;

2. APACHEII score is more than 8 and Ranson score is greater than 3;

3. Age 18-75;

4. Obtaining informed consent.

Exclusion Criteria:

1. Pregnancy pancreatitis;

2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.

Related Conditions & MeSH terms

• Acute Pancreatitis
• Multiple Organ Failure
• Organ Failure, Multiple
• Pancreatitis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Nanjing University School of Medicine

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the incidence rate of infected pancreatic necrosis		2-4 week after disease onset
Secondary	the incidence rate of organ failure	the incidence rate of organ failure (transient or persistent)	1-2 week after disease onset
Secondary	the incidence rate of local complications	acute peripancreatic fluid collections, pancreatic pseudocycts, acute necrotic collections and walled-off necrosis	1-2 week after disease onset