The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery

Acute Pain Clinical Trial

Official title:

The Influence of Different Anesthesia and Postoperative Pain Management on Acute and Chronic Postsurgical Pain After Thoracic Surgery: a Prospective Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03847363
• Other study ID #: cpsp-revisited
• Status: Recruiting
• Start date: April 1, 2018
• Est. completion date: July 30, 2020

Study information

• Verified date: February 2019
• Source: Shanghai Zhongshan Hospital
• Contact: shuwei wang
• Phone: +8613564440601
• Email: veronciawang228[@]126.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.

Description:

Chronic postsurgical pain (CPSP) was the pain caused by the operation that exceeded the healing time of normal tissue (usually 3 months), that was, a status that the damage caused by noxious stimulus had been healed, but the pain that cannot be explained by disease and inflammation were still existed. Due to the location of the incision and the necessity of indwelling the chest tube, the thoracic lung surgery was considered to be one of the most painful surgical operations. Studies have found that the incidences of CPSP in patients with thoracotomy were 57% (95% CI, 51-64%) and 47% (95% CI, 39-56%) at postoperative 3 and 6 months, respectively. With the development of minimally invasive techniques, thoracic surgery had gradually become less traumatic, and the number of surgical incisions was gradually developed into single port.Through ages, epidural analgesia with a combination of local anesthetics and opioids had long been considered the "gold standard" for postoperative analgesia in thoracic surgery. However, with the development of clinical anesthetics and the widespread use of nerve block techniques, it had been found that in open radical gastrectomy, there was no significant difference in the inhibition of intraoperative stress response between dexmedetomidine combined with general anesthesia and a combined general-epidural anesthesia. So, which anesthesia and analgesia method was "perfect" for a specific type of surgery procedure? This study would compare acute and chronic postsurgical pain in patients underwent different thoracic surgery procedure with different anesthesia and analgesia methods, and explore the influencing factors.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 600
• Est. completion date: July 30, 2020
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• ASA I-II

• underwent selective thoracic surgery

Exclusion Criteria:

• with severe cardiac, endocrine,immunologic or haematologic diseases

• medical history of chronic pain problems in chest area

• medical history of pain-relief or sedative medication

• not able to communicate with investigators

Related Conditions & MeSH terms

• Acute Pain
• Chronic Postsurgical Pain

Intervention

Procedure:
• epidural anesthesia
epidural anesthesia
• nerve block
paravertebral or serratus anterior plane block

Locations

Country	Name	City	State
China	Zhongshan Hospital, Fudan University	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Shanghai Zhongshan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	numerical rating scale of acute postsurgical pain	numerical rating scale is a 11-point scale for patient self-reporting of pain, in which 0 stands for no pain and 10 stands for the most severe pain.	at day1 post-operation
Primary	numerical rating scale of acute postsurgical pain	numerical rating scale is a 11-point scale for patient self-reporting of pain, in which 0 stands for no pain and 10 stands for the most severe pain.	at day2 post-operation
Primary	numerical rating scale of chronic postsurgical pain	numerical rating scale is a 11-point scale for patient self-reporting of pain, in which 0 stands for no pain and 10 stands for the most severe pain.	at 3rd month post-operation
Primary	numerical rating scale of chronic postsurgical pain	numerical rating scale is a 11-point scale for patient self-reporting of pain, in which 0 stands for no pain and 10 stands for the most severe pain.	at 6th month post-operation