Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy

Acute Pain Clinical Trial

Official title:

Ultrasound-guided Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy: Randomized Controlled Double-blinded Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02645903
• Other study ID #: TAP
• Status: Completed
• Phase: Phase 4
• First received: December 24, 2015
• Last updated: January 5, 2016
• Start date: May 2015
• Est. completion date: October 2015

Study information

• Verified date: January 2016
• Source: Inonu University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in liver transplantation donors in whom a right lateral extending upper mid-line abdominal incision was used.

Description:

This prospective randomized controlled double-blinded study was conducted with 50 liver transplantation donors between 18-65 years who were scheduled to undergo right hepatectomy surgery. Cases to whom TAP block with ultrasound was applied after standard general anesthesia were determined as Group 1 and cases to whom only standard general anesthesia was applied, were determined as Group 2.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: October 2015
• Est. primary completion date: October 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Liver transplantation donors

Exclusion Criteria:

• Patients with a history of allergy to the drugs used in the study protocol, coagulation pathology, opioid tolerance

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Pain

Intervention

Drug:
• Transversus Abdominis Plane Block
Cases to whom used bupivacaine with ultrasound guided transversus abdominis plane block was applied after standard general anesthesia were determined as Group 1
• standard general anesthesia
Cases to whom applied alone standard general anesthesia were determined as Group 2

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Inonu University

References & Publications (1)

Abdallah FW, Chan VW, Brull R. Transversus abdominis plane block: a systematic review. Reg Anesth Pain Med. 2012 Mar-Apr;37(2):193-209. doi: 10.1097/AAP.0b013e3182429531. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pain scores (at movement and at rest)	Pain scores were assessed using a visual analog scale (0: No pain, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10: Excruciating pain).	postoperatively at 24 hours	Yes
Secondary	morphine consumption	morphine consumption were measured in postoperatively 24 hours	postoperatively at 24 hours	Yes