Acute Pain Clinical Trial
Official title:
Efficacy and Safety of Nebulized Morphine Given at Two Different Doses Compared to Intravenous Morphine in Post-traumatic Acute Pain: a Randomized Controlled Double Blind Study
The investigators test a different technique using morphine to improve pain relief in
patient visiting the emergency department with acute trauma pain, for this we are comparing
three different methods of morphine administration:
- intravenous titrated morphine
- low dose nebulized morphine and
- high dose nebulized morphine
Trauma patients are frequent in emergency department settings, and often require urgent
care.
taking care of this patients consists on taking care of their pain and then the specific
treatment of their traumatic lesions.
actually, the most used medicine and most efficient one in treating pain is morphine, it's
mechanism of action is by acting on receptors located on neuronal cell membranes and inhibit
neurotransmitter release.
The most applied administration root of morphine is by intravenous (IV) titration or IV
continuous perfusion, but until now, there is no clear recommendation concerning the
superiority of this root over other administration techniques such as nebulization.
In this study we aimed to investigate the efficiency, the feasibility and the tolerance of
three morphine administration roots in patients with acute traumatic pain and to clarify the
most adequate one to apply in emergency department settings.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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