Acute Pain Clinical Trial
— RemiclonOfficial title:
Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
Verified date | August 2008 |
Source | Oslo University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Norway: Norwegian Medicines Agency |
Study type | Interventional |
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.
Status | Completed |
Enrollment | 12 |
Est. completion date | May 2005 |
Est. primary completion date | May 2005 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Healthy volunteers Exclusion Criteria: |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Norway | Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center | Oslo |
Lead Sponsor | Collaborator |
---|---|
Oslo University Hospital |
Norway,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Relief of pain(VAS reduction) | Experimental | No | |
Secondary | Reduction in Minute ventilation | Experimental | Yes | |
Secondary | Reduction in CO2 stimulated Minute Ventilation | experimental | Yes | |
Secondary | Reduction in BIS score | Experimental | No | |
Secondary | Performance on Stroop test | Experimental | No |
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