Acute Pain Clinical Trial
Official title:
A Randomized Clinical Trial Comparing Intravenous Morphine and Intravenous Hydromorphone in the Treatment of Adult ED Patients With Moderate to Severe Pain
Verified date | August 2018 |
Source | Montefiore Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this research study is to determine which opiate pain medication (morphine or hydromorphone (Dilaudid)) is more effective in the treatment of acute pain in patients presenting to the emergency department.
Status | Completed |
Enrollment | 194 |
Est. completion date | March 2007 |
Est. primary completion date | March 2007 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: 1. Age greater than 65 years 2. Pain with onset within 7 days 3. ED attending physician's judgment that patient's pain warrants use of parenteral opioids 4. Normal mental status Exclusion Criteria: 1. Prior use of methadone 2. Use of other opioids or tramadol within past seven days 3. Prior adverse reaction to morphine or hydromorphone 4. Chronic pain syndrome 5. Alcohol intoxication 6. Systolic Blood Pressure <90 mm Hg 7. Use of monoamine oxidase (MAO) inhibitors in past 30 days 8. Elderly patients with a capnometry reading of greater than 46 |
Country | Name | City | State |
---|---|---|---|
United States | Montefiore Medical Center | Bronx | New York |
Lead Sponsor | Collaborator |
---|---|
Montefiore Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Pain Intensity | Pain scores are a measure of pain intensity and are measured on the numerical rating scale (NRS), from 0 (no pain) to 10 (worst pain imaginable). Participants are asked to rate their pain using this scale at baseline before any medication is administered and again 30 minutes after medication is infused | Baseline to 30 minutes after medication infused | |
Secondary | Number of Participants With a Change in Pain Score | Pain score is a measure of pain intensity using the numerical rating scale (NRS), from 0 (no pain) to 10 (worst pain imaginable). Data is separated into two groups: those with greater than or equal to 50% change in their pain score and those with less than 50% change in their pain score. | Baseline to 30 minutes after medication infused | |
Secondary | Number of Participants With Pain Relief | Pain relief here is a subjective measure indicated by the following categories: No, Slight, Moderate, and Complete. Participants were asked to pick the category that best fit their level of pain relief 30 minutes after medication was infused. | 30 minutes after medication infused | |
Secondary | Number of Participants Satisfied With Pain Medication | Number of participants who were satisfied with pain medication received, based on their response of good to excellent or poor to fair. Participants were asked to pick which response best fit their satisfaction with the pain medication they received 30 minutes after that medication was infused "Good to Excellent" or "Poor to fair". | 30 minutes after medication infused |
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