Acute Otitis Media Clinical Trial
Official title:
Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children: A Randomized Controlled Trial
This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. The participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. The children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. The main outcomes of this trial are the changes in the intestinal microbiome after the treatment.
Antimicrobial treatment of acute otitis media has been proven efficacious in children. It has been suggested that antimicrobial treatment makes a lot of harm to intestinal microbiome and may thus have effects on the child's health and wellbeing. However, data on these changes and their magnitude is scanty. This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. The participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. The children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. The main outcomes of this trial are the changes in the intestinal microbiome after the treatment. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02092454 -
Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media
|
Phase 2 | |
Completed |
NCT01202578 -
Evaluation of the Tympanostomy Tube Delivery System
|
Phase 2/Phase 3 | |
Withdrawn |
NCT00502450 -
Is There Hearing Loss After Acute Mastoiditis
|
N/A | |
Completed |
NCT04296448 -
Evaluation of Cellphone Based Otoscopy in Pediatric Patients
|
N/A | |
Terminated |
NCT05651633 -
Analgesic Ear Drops for Children With Acute Otitis Media
|
Phase 3 | |
Completed |
NCT01941381 -
Does Tympanometry Predict Antibiotic Usage in Acute Otitis Media?
|
||
Completed |
NCT02345447 -
Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence
|
Phase 3 | |
Recruiting |
NCT01214538 -
Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children
|
N/A | |
Completed |
NCT03614117 -
Effect of a New Probiotic Strain on Recurrent Acute Otitis Media in Children (PROMAR)
|
N/A | |
Recruiting |
NCT06027593 -
Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
|
N/A | |
Completed |
NCT02918773 -
Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)
|
N/A | |
Completed |
NCT02567747 -
Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age
|
||
Completed |
NCT02567825 -
Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media
|
N/A | |
Completed |
NCT02037893 -
Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media
|
Phase 2 | |
Completed |
NCT00578773 -
A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea
|
Phase 2 | |
Completed |
NCT00377260 -
Acute Otitis Media (AOM) Therapy Trial in Young Children
|
Phase 4 | |
Completed |
NCT00645112 -
A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media
|
Phase 4 | |
Completed |
NCT00368823 -
A Trial of Point of Care Information in Ambulatory Pediatrics
|
Phase 3 | |
Completed |
NCT01272999 -
Impact of Prevnar 13 on Ear Infections in Children
|
||
Completed |
NCT01031082 -
Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children
|
N/A |