Acute on Chronic Liver Failure Clinical Trial
Official title:
A Randomized Controlled Trial of Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (SMT) in Improving Patient Survival and Immune Modulation in Patients With Acute on Chronic Liver Failure (ASIA Trial).
The AIM of the study is to study the efficacy of intravenous albumin and standard medical
treatment as compared to standard medical treatment alone in ameliorating/preventing SIRS and
improving survival at 28 days .The project will be conducted in ILBS from august 2018 to
December 2019Concept is to understand the immunology, pathophysiology and effects of albumin
in the management of ACLF for betterment of the patient's condition and early recovery.
All ACLF patients will be included as per the inclusion and exclusion criteria , after taking
informed consent from the patient or their relatives. Will be evaluated for the possible risk
factors for the development of SIRS/sepsis in ACLF patients and possible beneficial factors
for resolution of SIRS /sepsis in ACLF patients. The effects of albumin administration as per
this protocol versus standard medical treatment alone will be reviewed If patient develops
allergic reactions to albumin, fluid overload, albumin will be stopped and patient will be
treated accordingly to medical condition.
n/a
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