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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML

Acute Myeloid Leukemia (AML) Clinical Trial

Official title:
Phase 1, Open-label, Study of Voruciclib in Subjects With Relapsed and/or Refractory B Cell Malignancies or AML After Failure of Prior Standard Therapies and Voruciclib in Combination With Venetoclax in Subjects With Relapsed/Refractory AML

Clinical Trial Summary

This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML

Clinical Trial Description

This is a Phase 1, open-label, 3 + 3 dose escalation and expansion study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of prior standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML. Escalation to the next higher dose level will depend on demonstrated safety and tolerability at each dose level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03547115
Study type Interventional
Source MEI Pharma, Inc.
Contact MEI Pharma
Phone 858-369-7100
Email Patients@meipharma.com
Status Recruiting
Phase Phase 1
Start date May 31, 2018
Completion date March 31, 2025
View Details
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