The Effects of Intermittent Hypoxia on Acute Hypoxic Injury

Status Recruiting

Clinical Trial Summary

This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.

Clinical Trial Description

Acute exposure to hypoxia can induce acute hypoxic injury (AHI), according to the severity of the injury, it can be divided into acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE). AMS is the most common type, it mostly occurs within 6-12 hours after rapidly entering the altitude above 2500m, sometimes within 1h, and can be manifested as headache, nausea, diarrhea, sleep disorders, etc. The incidence of AMS at the altitude of 2500-3000m is 10-20%, which reaches 50-85% at 4500-5000m above sea level. Intermittent hypoxia (IH) refers to periodic hypoxic-normoxic training performed with brief exposure to hypoxia. Previous studies have found that short-term intermittent hypoxia can increase the sensitivity of hypoxia and reduce the severity of acute hypoxia injury, and alleviate acute hypoxia injury by reducing the inflammatory response caused by hypoxia. Therefore, this study aims to conduct a randomized controlled trial to further reveal the effectiveness of IH and explore its potential mechanisms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05733338
Study type	Interventional
Source	Capital Medical University
Contact	Yuan Wang, M.D.
Phone	+86-135 8156 7815
Email	wilma0106@163.com
Status	Recruiting
Phase	N/A
Start date	March 1, 2023
Completion date	April 30, 2023

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