Clinical Trials Logo
  1. Home
  2. Acute Mountain Sickness
  3. NCT03561675

Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years

Acute Mountain Sickness Clinical Trial

Official title:
Acetazolamide for Prevention of Acute Mountain Sickness in Healthy Lowlanders Older Than 40 Years. Randomized Trial.

Clinical Trial Summary

Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.

Clinical Trial Description

This is a randomized, placebo-controlled, double-blind parallel trial evaluating the efficacy of acetazolamide prophylaxis in reducing the incidence of acute mountain sickness (AMS) in lowlanders older than 40 years travelling to altitude. Participants living in the Bishkek area, Kyrgyzstan (760m), will be transferred by car within 4h to the Tuja Ashu high altitude clinic (3'100 m), and stay there for 2 days. Acetazolamide 375mg/day (or placebo), will be administered before departure at 760 m and during the stay at altitude. Outcomes will be assessed during the stay at 3'100 m. An interim analysis will be carried out when 80 participants will have completed the study or after the first year. The Peto's method will be used and the trial will be stopped when pre-specified futility boundaries were crossed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03561675
Study type Interventional
Source University of Zurich
Contact
Status Completed
Phase Phase 4
Start date May 15, 2018
Completion date August 31, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT04111263 - Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude N/A
Completed NCT01842906 - Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID) N/A
Completed NCT01536288 - Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness Phase 2
Completed NCT00326703 - Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort N/A
Completed NCT06310642 - Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness Phase 4
Completed NCT00559832 - Prevention of Acute Mountain Sickness by Intermittent Hypoxia N/A
Completed NCT01436383 - Oxidative Stress in Hypobaric Hypoxia N/A
Completed NCT00603122 - Acclimatization Mechanisms During Ascent to 7500m N/A
Completed NCT00664001 - Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Phase 3
Completed NCT00627965 - Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Phase 4
Not yet recruiting NCT06145113 - The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness N/A
Recruiting NCT05733338 - The Effects of Intermittent Hypoxia on Acute Hypoxic Injury N/A
Completed NCT01522326 - Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness N/A
Recruiting NCT06393998 - CO2 Supplement for Treatment of Acute Mountain Sickness N/A
Completed NCT03270787 - Study of Compound Danshen Dripping Pills to Treat Acute Mountain Sickness Phase 1/Phase 2
Completed NCT02811016 - Inhaled Budesonide and Acute Mountain Sickness Phase 1
Recruiting NCT00886912 - Training in Hypoxia to Prevent Acute Mountain Sickness N/A
Terminated NCT03956472 - Alternative Treatments in Acute Mountain Sickness N/A
Recruiting NCT03621410 - T89 in Prevention and Treatment of Acute Mountain Sickness (AMS) During Rapid Ascent Phase 2
Active, not recruiting NCT01565603 - Sleep and Cerebral Responses to High Altitude N/A