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NCT01922557 Clinical Trial

Thoracic Fluid Content and Acute Lung Injury

Acute Lung Injury Clinical Trial

Official title:
The Association of Thoracic Fluid Content and Acute Lung Injury in Liver Transplantation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01922557
Other study ID # 201012081RC
Secondary ID
Status Completed
Phase N/A
First received July 11, 2013
Last updated August 12, 2013
Start date January 2011
Est. completion date June 2012

Study information
Verified date August 2013
Source National Taiwan University Hospital
Contact n/a
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

To study the association of the thoracic fluid content and acute lung injury during liver transplantation.

Description:

Acute lung injury is not uncommon after liver transplantation. A new monitor non-invasive cardiac output monitor (NICOM) is designed to measure thoracic fluid content. The investigators attempt to use the parameter thoracic fluid content to investigate its relationship with acute lung injury in liver transplant recipients.

Recruitment information / eligibility
Status Completed
Enrollment 22
Est. completion date June 2012
Est. primary completion date January 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- end stage liver disease scheduled for liver transplantation in National Taiwna University Hospital.

Exclusion Criteria:

- allergic reaction

- history of aortic regurgitation

- pre-existing pulmonary disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Device:
• NICOM
NICOM monitoring thoracic fluid content at baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4).

Locations
Country Name City State
Taiwan Department of Anesthesiology, NTUH Taipei

Sponsors (1)
Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Hong SK, Hwang S, Lee SG, Lee LS, Ahn CS, Kim KH, Moon DB, Ha TY. Pulmonary complications following adult liver transplantation. Transplant Proc. 2006 Nov;38(9):2979-81. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Cardiac index Participants will be followed for the duration the operation. Cardiac index was measured by non-invasive cardiac output monitor at different time points as baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4) one day No
Secondary Thoracic fluid content Participants will be followed for the duration the operation.Thoracic fluid content was measured in liver transplant recipients at different time points as baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4). one day No
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