Acute Lung Injury Clinical Trial
— TPG in HFOOfficial title:
Transpulmonary Pressure Gradients in High Frequency Oscillation Study
Verified date | March 2014 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Observational |
Patients with severe lung conditions occasionally require support with a special ventilator (breathing machine) called the High Frequency Oscillator (HFO). Effective ventilation requires that the pressure generated by the ventilator be as high as possible but not too high as this can damage the lungs. In patients on HFO, there is not a well defined way to measure this pressure. We will insert a small probe into the esophagus of patients on HFO to see if this is an accurate way to measure lung pressures for these patients. A better understanding of these pressures could lead to improved patient care.
Status | Completed |
Enrollment | 7 |
Est. completion date | March 2013 |
Est. primary completion date | July 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 19 Years and older |
Eligibility |
Inclusion Criteria: - 19 years of age or older - Receiving HFO - Informed Consent Obtained Exclusion Criteria: - Esophageal lesions or esophageal surgery within the last 6 months - Morbid obesity - defined as a Body Mass Index (BMI) > 40 - Unstable cervical spine injury or cervical spinal cord injury |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Canada | Vancouver General Hospital | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To demonstrate the proof of concept that esophageal pressures can easily be obtained in patients undergoing HFO. | 60 minutes | No | |
Secondary | To determine the transpulmonary pressure gradient in critically ill patients receiving HFO | 60 minutes | No |
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