Acute Lung Injury Clinical Trial
Official title:
Transpulmonary Pressure Gradients in High Frequency Oscillation Study
Patients with severe lung conditions occasionally require support with a special ventilator (breathing machine) called the High Frequency Oscillator (HFO). Effective ventilation requires that the pressure generated by the ventilator be as high as possible but not too high as this can damage the lungs. In patients on HFO, there is not a well defined way to measure this pressure. We will insert a small probe into the esophagus of patients on HFO to see if this is an accurate way to measure lung pressures for these patients. A better understanding of these pressures could lead to improved patient care.
Trials have found that the use of lower tidal volumes (6 ml/kg) during conventional
mechanical ventilation decreases morbidity and mortality. Compared to conventional
ventilation, high frequency oscillation (HFO) is able to provide much smaller tidal volumes
(1.1 - 2.5 ml/kg) and thus theoretically may provide additional lung protection. At this
time, while trials of HFO in adults have been inconclusive, the use of HFO for the
management of ALI/ARDS has become widespread
Patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are
critically ill and have a high mortality associated with their illness (approximately 50%).
Currently, esophageal pressure monitors are used to optimize inflation pressures and improve
oxygenation in conventional mechanical ventilation in patients with ALI/ARDS. With this in
mind, the purpose of this study is twofold: (1) demonstrate that esophageal pressure
monitors can easily be inserted in patients undergoing HFO and (2) report the transpulmonary
pressures in these patients.
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Observational Model: Cohort, Time Perspective: Prospective
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