Modulation of Lung Injury Complicating Lung Resection

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.

Clinical Trial Description

Acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. Management of these patients is largely supportive. Even in patients who do not develop clinical evidence of acute lung injury, markers of inflammation and oxidative stress are present in blood and exhaled breath condensate after lung resection. The purpose of this randomised double-blind placebo-controlled study is to determine whether lung injury can be prevented by pre-administration of N-acetylcysteine. ;

Study Design

Related Conditions & MeSH terms

Acute Lung Injury
Lung Injury
Respiratory Distress Syndrome, Adult
Wounds and Injuries

Clinical Trial Details

NCT number	NCT00655928
Study type	Interventional
Source	Imperial College London
Contact
Status	Completed
Phase	Phase 2
Start date	August 2007
Completion date	July 2009

View Details

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