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Real-time Early Detection of Nephrotoxicity by Urinary Biomarker Analysis With SeroFlow Technology — RenaFAST  

Acute Kidney Injury Clinical Trial

Official title:
Real-time Early Detection of Nephrotoxicity by Accurate and Faster Urinary Biomarker Analysis With SeroFlow Technology (RenaFAST Study)

Clinical Trial Summary

The study aims to perform real-time validation of the RenaFAST kit (a point-of-care test kit that quantifies three urinary proteins) in predicting acute kidney injury(AKI) among patients prescribed drug therapies of nephrotoxic potential. Based on the type and duration of drug therapy, a maximum of 5 time-point urine samples will be collected from consenting patients and a real-time biomarker analysis will be conducted using the RenaFAST kits.

Clinical Trial Description

All eligible patients who fulfill the inclusion and exclusion criteria will be approached for consent. The patients with the highest AKI risk (with all 3 urine biomarkers, Clusterin, monocyte chemoattractant protein-1 (MCP1), and Beta-2 microglobulin (ß2MG), above prediction threshold set by the study) will be identified. The nephrology consultants within the research team will perform a medical chart and physical review(where required) of these patients, noting potential actions to be taken in data collection forms. This will help in evaluating if indeed there are perceived interventions that could potentially be delivered in response to early prediction of AKI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06124885
Study type Interventional
Source National University Hospital, Singapore
Contact Horng-Ruey Dr Chua
Phone 67722544
Email horng_ruey_chua@nuhs.edu.sg
Status Recruiting
Phase N/A
Start date November 2023
Completion date December 2024
View Details
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