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NCT06108362 Clinical Trial

Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients

Acute Kidney Injury Clinical Trial

Official title:
Effect of Intraoperative Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients: a Randomized, Double-blind, Placebo-controlled Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06108362
Other study ID # 23344-4-02
Secondary ID
Status Recruiting
Phase Phase 4
First received
Last updated
Start date August 18, 2023
Est. completion date June 30, 2024

Study information
Verified date August 2023
Source Beijing Tsinghua Chang Gung Hospital
Contact Ziheng Qi, Doctor
Phone 15373598688
Email 469836626@qq.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation. Patients were randomly divided into experimental group and control group by numerical randomization table. The experimental group was injected with terlipressin perioperative and the control group was injected with placebo

Description:

acute kidney injury is a relatively common complication in patients with liver transplantation. Most centers have established prediction models for acute kidney injury after liver transplantation, but the incidence cannot be reduced through perioperative anesthesia management. As an vasopressin receptor agonist, terlipressin can increase blood pressure and improve kidney perfusion at the same time, and perioperative application may reduce the incidence of postoperative acute kidney injury

Recruitment information / eligibility
Status Recruiting
Enrollment 104
Est. completion date June 30, 2024
Est. primary completion date June 30, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - 1) Patients who plan to undergo liver transplantation in our hospital 2) Patients or family members sign informed consent Exclusion Criteria: - Patients <18 years old;? Patients undergoing autologous liver transplantation or combined transplantation;? Patients with lower extremity artery stenosis;(4) Patients with severe heart disease?lung disease?kidney disease;? Patients with severe lung disease;? Patients who used renal replacement therapy before surgery;? the depth of one kidney from the body surface is greater than 4cm;? Patients treated with terlipressin within 2 weeks before surgery? Patients allergic to terlipressin.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Terlipressin
The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins
• normal saline
The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

Locations
Country Name City State
China Beijing Tsinghua Chang Gung Hospital Beijing Beijing

Sponsors (1)
Lead Sponsor Collaborator
Beijing Tsinghua Chang Gung Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Incidence of acute kidney injury after liver transplantation acute kidney injury diagnostic criteria (2012 edition) in 7 days
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