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NCT05924269 Clinical Trial

Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)

Acute Kidney Injury Clinical Trial

— NEUKID  

Official title:
Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05924269
Other study ID # NEUKID
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date August 2023
Est. completion date July 2026

Study information
Verified date June 2023
Source University Hospital Tuebingen
Contact Andreas Körner, MD
Phone +497071-29 61783
Email andreas.koerner@med.uni-tuebingen.de
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care. The diagnosis of acute kidney injury is based solely on urine output and serum creatinine, both of which could also be influenced by other factors. A more sensitive and faster diagnostic option would not only be desirable but of utmost clinical importance. Therefore, the investigators aim to identify Neuronal Guidance Proteins (NGPs) as potential biomarkers for the identification and early detection of AKI with this investigation. This investigation aims to identify the possibility of diagnosing acute kidney injury, the subsequent validation of a potential biomarker will then have to take place in a multicenter study approach: Data in preclinical mouse models suggest that SEMA7A as one of the NGPs could be valuable as a biomarker, the study now aims to attempt a preliminary survey in humans and measure various NGPs.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 600
Est. completion date July 2026
Est. primary completion date July 2026
Accepts healthy volunteers No
Gender All
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria: - Patients undergoing cardiac surgery - written consent Exclusion Criteria: - no written consent possible - Polytrauma, severe burns - Immunosuppression - Pregnancy - Diagnosis of Hepatitis B, Hepatitis C, and/or HIV - Sepsis - Pre-existing kidney damage

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Tuebingen

Outcome
Type Measure Description Time frame Safety issue
Primary AKI Development of AKI after cardiac surgery 1-7 days
Secondary NGP Concentration of NGPs in Blood and Urine 1-7 days
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