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NCT05672238 Clinical Trial

Evaluation of Postoperative Acute Kidney Injury (AKI) Incidence and Risk Factors in Patients Underwent Pneumonectomy

Acute Kidney Injury Clinical Trial

Official title:
Evaluation of Postoperative Acute Kidney Injury (AKI) Incidence and Risk Factors in Patients Underwent Pneumonectomy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05672238
Other study ID # AnkaraUPneumonectomyAKI
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 16, 2021
Est. completion date November 18, 2022

Study information
Verified date January 2023
Source Ankara University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. The aim of this study is to identify the incidance and outcomes of patients underwent pneumonectomy, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria.

Description:

Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. Although there is a decrease in pulmonary damage with restrictive fluid management and protective ventilatory strategies in patients who underwent wide lung resection to prevent pulmonary edema development after resection, the relative hypovolemia and hypoperfusion developed in patients may lead to renal dysfunction. The incidence of AKI after thoracic surgery can be up to 15% and is associated with prolonged length of stay (LOS) in hospital. The incidence of AKI is higher in patients with extensive resection such as pneumonectomy compared with lobectomy and wedge resection. Since AKI is not only a rare complication but also a risk factor for mortality, it is important to identify the incidence and risk factors of AKI, to prevent AKI and related complications and to improve patients outcomes. In this study incidence of AKI was defined using the KDIGO criteria according to the change of serum creatine levels. 166 patients who underwent pneumonectomy from January 2008 to December 2018 included the retrospective observational study. Demographic data, intraoperative data, rates of complications, risk factors for AKI, mortality, lenght of stay in intensive care unit (İCU) and hospital were evaluated. AKI was defined using the KDIGO criteria according to the serum creatinine levels. The SPSS 11.5 program was used for statistical analysis.

Recruitment information / eligibility
Status Completed
Enrollment 166
Est. completion date November 18, 2022
Est. primary completion date October 28, 2022
Accepts healthy volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Patients underwent pneumonectomy, from January 2008 to December 2018 Exclusion Criteria: - Chronic Kidney Disease

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey Ankara University Ankara

Sponsors (7)
Lead Sponsor Collaborator
Ankara University Basak Ceyda MECO, Bengi Safak, Çigdem Yildirim Güçlü, Islam Aktürk, Süleyman Gökalp Günes, Yusuf KAHYA

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Postoperative acute kidney injury in patients underwent pneumonectomy Kidney Disease Improving Global Outcomes (KDIGO) criteria One week
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