Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Acute Kidney Injury Clinical Trial

Official title:

Association Between Preoperative Level of Hemoglobin A1c and the Incidence of Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery: a Cohort Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05390281
• Other study ID #: FMASU MD 368/2018
• Status: Completed
• Start date: June 1, 2019
• Est. completion date: October 1, 2020

Study information

• Verified date: May 2022
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: October 1, 2020
• Est. primary completion date: July 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 45 Years to 70 Years

Eligibility

Inclusion Criteria:

• ASA physical status II-III

• scheduled to undergo isolated coronary artery bypass grafting

Exclusion Criteria:

• Patients with history of renal failure

• Patients with history of hepatic failure

• Patients with history of heart failure

• previous cardiac surgery

• cerebrovascular event in the last 30 days

• percutaneous coronary intervention in the last 30 days prior to operation

• peripheral arterial disease

• malignancy

• infectious diseases

• patients who required surgical revision

• patients who required postoperative intra-aortic balloon pump

• patients with CBP time > 120 min or aortic cross clamp time > 90 min

Related Conditions & MeSH terms

• Acute Kidney Injury
• Wounds and Injuries

Intervention

Diagnostic Test:
• increase in serum creatinine
any of the following: increase in serum creatinine by = 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Locations

Country	Name	City	State
Egypt	Ain-Shams University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Length of ICU stay	The duration of postoperative patient stay in the intensive care	7days
Primary	serum creatinine level	increase in serum creatinine by = 0.3 mg/dl within 48 h of surgery or increase in serum creatinine to = 1.5 times baseline within 3 days of cardiac surgery	3 days
Secondary	Patients in need of RRT	The number of patients requiring postoperative renal replacement therapy	7 days