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Renal Tolerance of Amoxicillin and Cloxacillin Combination — Amox-Cloxa  

Acute Kidney Injury Clinical Trial

Official title:
Incidence of Actue Kidney Injury in Patients Treated With Amoxicillin and Cloxacillin Combination Therapy

Clinical Trial Summary

2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identiļ¬cation). Yet this combination has never been studied in clinical trials. High dose penicillin treatments are associated with a risk of nephrotoxicity. The investigator's primary purpose is to describe patients treated with high dose Amoxicillin and Cloxacillin combination and to evaluate its renal tolerance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05142891
Study type Observational
Source University Hospital, Strasbourg, France
Contact Yvon RUCH, MD
Phone 33 3 88 11 66 90
Email yvon.ruch@chru-strasbourg.fr
Status Recruiting
Phase
Start date October 15, 2021
Completion date October 30, 2022
View Details
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