Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery

Status Recruiting

Clinical Trial Summary

This is a randomized, open label study to investigate vasopressin versus phenylephrine as a first line pressor in cardiac surgery. All patients >18 years of age presenting for coronary artery bypass graft (CABG), valve surgery, or combined CABG and valve surgery will be screened for inclusion. Patients with ejection fraction < 35%, > moderate pulmonary hypertension, > mild right ventricular dysfunction, a planned radial arterial graft, or circulatory arrest will be excluded. Patients will be randomized to receive either vasopressin or phenylephrine as the first line vasopressor during the perioperative period to maintain mean arterial blood pressure >65 mmhg. Primary outcome is acute kidney injury. Secondary outcomes are 30-day mortality, stroke, myocardial infarction, re-operation, sternal infection, atrial fibrillation, intensive care unit length of stay, and total vasopressor hours.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Kidney Injury

Clinical Trial Details

NCT number	NCT04602767
Study type	Interventional
Source	Thomas Jefferson University
Contact	Jenifer Lessin
Phone	215 955-5804
Email	jennifer.lessin@jefferson.edu
Status	Recruiting
Phase	Phase 4
Start date	October 15, 2020
Completion date	October 1, 2024

View Details

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