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Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? — VITAKI  

Acute Kidney Injury Clinical Trial

Official title:
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? A Multicenter Randomized Controlled Study

Clinical Trial Summary

Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting. Many experimental and clinical data suggest that Nicotinamide, a safe and inexpensive vitamin, could be effective to prevent major adverse kidney events during septic shock. The main objective of the study is to show the superiority of Nicotinamide supplementation compared to the placebo group, in patients with septic shock admitted to intensive care. A 15% reduction in the incidence of major renal adverse events at day 30 is expected in the "Nicotinamide" group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04589546
Study type Interventional
Source Centre Hospitalier Universitaire, Amiens
Contact Dimitri Titeca-Beauport, MD
Phone 0322456411
Email dimitri.titeca@chu-amiens.fr
Status Recruiting
Phase Phase 3
Start date October 1, 2020
Completion date January 2024
View Details
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