Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Acute Kidney Injury Clinical Trial

Official title:

Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04310514
• Other study ID #: 04-0532/09/776
• Status: Recruiting
• Phase: N/A
• Start date: March 9, 2020
• Est. completion date: December 31, 2020

Study information

• Verified date: March 2020
• Source: Medical University of Gdansk
• Contact: Wojciech Wolyniec, MD,PhD
• Phone: 48 600942998
• Email: wolyniecwojtek[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Rehydration during and after physical exercise is essential to avoid acute kidney injury.

Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.

30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.

Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 31, 2020
• Est. primary completion date: September 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• age above 18 years

• well-trained soccer players

• informed consent

Exclusion Criteria:

• chronic diseases, especially kidney problems

• sigificant changes in urinalysis

• creatinine level above normal values

Related Conditions & MeSH terms

• Acute Kidney Injury
• Wounds and Injuries

Intervention

Dietary Supplement:
• Fructose/glucose/xylitol/saccharose
Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.

Locations

Country	Name	City	State
Poland	Medical University of Gdansk	Gdansk

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Gdansk

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise		after 60-90 min of pysical exercise
Primary	Changes in fractional uric acid excretion		after 60-90 min of pysical exercise