Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement

Acute Kidney Injury Clinical Trial

Official title:

Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04132921
• Other study ID #: XYFY2020-KL050-01
• Status: Recruiting
• Start date: October 25, 2019
• Est. completion date: November 1, 2020

Study information

• Verified date: October 2019
• Source: Xuzhou Medical University
• Contact: Jindong Liu, M.S
• Phone: +86-13951355136
• Email: liujindong1818[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function. Acute kidney injury is a common complication after total hip arthroplasty. Previous studies have shown that the incidence of acute kidney injury after hip replacement is as high as 21.9%. Acute kidney injury has become a global safety issue, and the occurrence of acute kidney injury can lead to an increase in hospital stay, medical costs and increased risk of death.There is currently no global survey of the incidence of AKI, and only a number of studies have been conducted on specific patient groups (eg, inpatients, intensive care units [ICU] patients or children) due to differences in study design and definition of acute kidney injury.

Description:

The incidence and prevalence of different studies vary widely, ranging from 0.32% to 44.30%. There are few studies on the risk factors associated with acute kidney injury after total hip arthroplasty, and early acute kidney injury is often overlooked due to the limitations of the current KDIGO-based diagnostic method. Therefore, it is particularly important for clinicians to understand the risk factors for postoperative acute kidney injury .

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1500
• Est. completion date: November 1, 2020
• Est. primary completion date: June 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Patients age 65 or older

• One-sided joint replacement;

• ASA score grade I-III

Exclusion Criteria:

• Emergency surgery patients;

• Patients with severe liver and kidney dysfunction;

• Missing related data;

• Serious systemic diseases before surgery;

Related Conditions & MeSH terms

• Acute Kidney Injury
• Wounds and Injuries

Locations

Country	Name	City	State
China	The Affiliated Hospital of Xuzhou Medical University	Xuzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Xuzhou Medical University

Country where clinical trial is conducted

China, 

References & Publications (5)

Bjerregaard LS, Jorgensen CC, Kehlet H; Lundbeck Foundation Centre for Fast-Track Hip and Knee Replacement Collaborative Group. Serious renal and urological complications in fast-track primary total hip and knee arthroplasty; a detailed observational coho — View Citation

Magder SA. The highs and lows of blood pressure: toward meaningful clinical targets in patients with shock. Crit Care Med. 2014 May;42(5):1241-51. doi: 10.1097/CCM.0000000000000324. Review. — View Citation

Maheshwari K, Turan A, Mao G, Yang D, Niazi AK, Agarwal D, Sessler DI, Kurz A. The association of hypotension during non-cardiac surgery, before and after skin incision, with postoperative acute kidney injury: a retrospective cohort analysis. Anaesthesia. — View Citation

Salmasi V, Maheshwari K, Yang D, Mascha EJ, Singh A, Sessler DI, Kurz A. Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery: A — View Citation

Yang L, Xing G, Wang L, Wu Y, Li S, Xu G, He Q, Chen J, Chen M, Liu X, Zhu Z, Yang L, Lian X, Ding F, Li Y, Wang H, Wang J, Wang R, Mei C, Xu J, Li R, Cao J, Zhang L, Wang Y, Xu J, Bao B, Liu B, Chen H, Li S, Zha Y, Luo Q, Chen D, Shen Y, Liao Y, Zhang Z, — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence and outcome of AKI after joint replacement	AKI can be diagnosed if one of the following conditions is true: (1) Serum creatinine increases by =26.5 µmol/L (0.3 mg / dl) within 48 h; (2)Serum creatinine rises more than 1.5 times of the baseline value, and is significantly or presumably the above situation occurred within 7 days;	Within 7 days after surgery
Secondary	Possible risk factors for AKI after joint replacement	Patient's age, gender, height, weight	1 day before surgery
Secondary	Intraoperative fluid volume and infusion type	Record the total amount of infusion and infusion type of during surgery	during sugery and within 7days after surgery
Secondary	Hemodynamic changes	Focus on the fluctuation of mean arterial pressure	during sugery and within 7days after sugery
Secondary	Factors related to anesthesia	Record the type and dose of anesthetic used in the procedure	during sugery and within 7days after sugery