Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury

Status Completed

Clinical Trial Summary

Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congestion and its clinical implications. The objective of this study is to determine whether ultrasound markers of organ congestion are associated with major adverse kidney events in critically ill patients with severe acute kidney injury.

Clinical Trial Description

Background: Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a direct mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congestion and its clinical implications. Objective: To determine whether ultrasound markers of organ congestions are associated with major adverse kidney events and other adverse clinical outcomes. Study design: A cohort of critically ill patients with a new onset of severe acute kidney injury will undergo repeated ultrasound assessments to detect the presence of the following markers: - Portal flow pulsatility on pulse-wave Doppler - Discontinuous intra-renal venous flow on pulse-wave Doppler - Abnormal hepatic vein waveform on pulse wave Doppler - Presence of pulmonary B-line artifacts on 2D lung ultrasound - Presence of dilated and non-collapsible inferior vena cava on 2D ultrasound - Presence of systolic right ventricular dysfunction - Presence of systolic left ventricular dysfunction Clinical outcomes will be collected for up to 90 days after recruitment. Perspective: An approach targeting the resolution of organ congestion might improve the prognosis in patients with severe acute kidney injury. Identifying clinically relevant markers of organ congestion is a precursor to the design of future interventional trials investigating personalized fluid balance management. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04095143
Study type	Observational
Source	Centre hospitalier de l'Université de Montréal (CHUM)
Contact
Status	Completed
Phase
Start date	September 4, 2018
Completion date	September 1, 2022

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury — ECHO-AKI

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms