Acute Kidney Injury Clinical Trial
Official title:
The Relationship Between IRRIV and RFR Under Pathologic Conditions
The assessment of renal functional reserve (RFR) has been proposed for the risk stratification of patients undergoing potentially nephrotoxic procedures. The present pilot study is designed to explore the correlation between IRRIV and RFR under pathologic conditions.
Renal functional reserve (RFR) represents the capacity of the kidney to increase glomerular
filtration rate (GFR) in response to certain physiological or pathological stimuli or
conditions.
RFR is calculated as the difference between the measured maximum GFR achieved through a renal
stress test and the baseline GFR measured in rest conditions. In clinical practice, the most
common renal stress test is performed as a standardized protein loading test. Recently, in a
pilot study, the investigators demonstrated a significant correlation between RFR and the
intra-parenchymal renal resistive index variation (IRRIV) during an echo renal stress test in
a cohort of healthy volunteers. IRRIV test has proven to be rapid, safe, bedside and easy to
perform and it might represent a preliminary test in screening patients' RFR.The present
pilot study is designed to explore the correlation between IRRIV and RFR under pathologic
conditions.
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