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NCT03469765 Clinical Trial

(TIMP-2)x(IGFPB7) to Predict Acute Kidney Injury (AKI) in Aortic Surgery

Acute Kidney Injury Clinical Trial

— TIGER  

Official title:
(TIMP-2)x(IGFPB7) as Early Renal Biomarker for the Prediction of Acute Kidney Injury in Aortic Surgery - an Observational Study (TIGER)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03469765
Other study ID # TIGER
Secondary ID
Status Completed
Phase
First received
Last updated
Start date June 19, 2018
Est. completion date September 23, 2019

Study information
Verified date September 2019
Source University Hospital Inselspital, Berne
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

New biomarkers that predict the development of renal dysfunction in patients with aortic surgery are urgently needed. The investigators investigate whether urinary (TIMP-2)x(IGFBP7) predicts postoperative Acute Kidney Injury and/or need for Renal Replacement Therapy (RRT) in patients after aortic surgery (including EVAR).

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date September 23, 2019
Est. primary completion date September 23, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients in need of emergency or elective abdominal aortic surgery (infra- or suprarenal clamping or EVAR) are eligible for study inclusion.

Exclusion Criteria:

- Patients unable to give informed consent

- Age < 18

- Patients not speaking German or French.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• does not apply
biological sample taking: urine, blood

Locations
Country Name City State
Switzerland Inselspital Bern

Sponsors (1)
Lead Sponsor Collaborator
Jörg Schefold

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Statistically significant difference in mean total (TIMP-2)x(IGFBP7) values of patients with/ without AKI (as defined along Kidney Disease Initiative for Improvement of global outcomes (KDIGO) definitions: stages 1-3) at the first postoperative day. 24 hours following ICU admission
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