Acute Kidney Injury Following Cardiac Surgery

Acute Kidney Injury Clinical Trial

Official title:

Acute Kidney Injury After Cardiac Surgery - A Retrospective Single-center Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03102528
• Other study ID #: 79/16 D
• Status: Completed
• Start date: November 1, 2014
• Est. completion date: June 20, 2016

Study information

• Verified date: August 2019
• Source: University of Giessen
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population. The investigators sought to examine the risk factors associated with the development of AKI and renal recovery in patients undergoing cardiac surgery at San Bortolo Hospital, Italy 2014-2015.

Description:

Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population. The investigators sought to examine the risk factors associated with the development of AKI and renal recoveryin patients undergoing cardiac surgery at San Bortolo Hospital, Italy during November 2014 - October 2015.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 495
• Est. completion date: June 20, 2016
• Est. primary completion date: October 31, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Adult cardiac surgery

Exclusion Criteria:

1. Missing baseline serum creatinine (defined as a serum creatinine value within 90 prior to surgery) or missing serum creatinine within 3 days before hospital discharge

2. Stage 5 chronic kidney disease (estimated glomerular filtration rate <15 ml/min/1.73 m2 or receipt of chronic dialysis)

3. Solid organ transplant recipients

Related Conditions & MeSH terms

• Acute Kidney Injury
• Wounds and Injuries

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Giessen

References & Publications (2)

Pickering JW, James MT, Palmer SC. Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies. Am J Kidney Dis. 2015 Feb;65(2):283-93. doi: 10.1053/j.ajkd.2014.09.008. Epub 2014 Nov 5. Review. — View Citation

Rydén L, Sartipy U, Evans M, Holzmann MJ. Acute kidney injury after coronary artery bypass grafting and long-term risk of end-stage renal disease. Circulation. 2014 Dec 2;130(23):2005-11. doi: 10.1161/CIRCULATIONAHA.114.010622. Epub 2014 Sep 19. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of acute kidney injury using full Kidney Disease Improving Global Outcomes criteria	Development of AKI within 7 days.	within 7 days
Secondary	Renal recovery	Defined as the absence of any stage of AKI by either serum creatinine or urine output criteria at hospital discharge.	Within 1 month