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PREdicting RENAL Injury In Patient After Hip Fracture Surgery — PRE-RENAL  

Acute Kidney Injury Clinical Trial

Official title:
The Use of Urinary MALDI-MS in Predicting Post-Operative Acute Kidney Injury in Patients After Fixation of Fractured Neck of Femur.

Clinical Trial Summary

To determine whether MALDI, a type of Mass-Spectometry, can use protein pattern detection within urine to predict postoperative (after an operation) kidney damage in adults who have undergone emergency hip fracture surgery?

Clinical Trial Description

The PRE-RENAL study is a prognostic accuracy study testing the ability of the MALDI-MS assay to predict incident acute kidney injury after fractured neck of femur surgery. The study aims to validate the findings of a urinary peptide panel previously developed and validated on a cohort of septic patients. Kidney injury following surgery or as a part of severe illness is an important complication, because it can delay and reduce the chances of recovery. A reliable early test for kidney injury would be useful so that treatments to prevent or minimise it can be started as early as possible. This study, based with a group of medical researchers working with chemists, will analyse clinical urine specimens from patients undergoing major orthopaedic (bone) surgery. We will explore whether patterns of proteins in the urine could be used as an early warning that kidney injury is present before existing tests demonstrate it. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03049150
Study type Observational
Source University of Edinburgh
Contact
Status Completed
Phase
Start date February 3, 2017
Completion date January 9, 2020
View Details
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