Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit

Acute Kidney Injury Clinical Trial

Official title:

Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02879201
• Other study ID #: 036/59
• Secondary ID: Vajira002
• Status: Completed
• Phase: N/A
• Start date: January 2009
• Est. completion date: June 2016

Study information

• Verified date: August 2023
• Source: Bangkok Metropolitan Administration Medical College and Vajira Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day . The secondary outcome were recovery of renal function, complications during therapy and duration of hospitalization.

Description:

The investigators performed a single center experience accumulated over 12 months since February 2009 with a continuous venovenous hemodiafiltration (CVVHDF) and hybrid technique named sustained low-efficiency dialysis (SLED). The primary end point was death from any cause by day 30. Intensive care unit (ICU) patients were eligible for inclusion when serum creatinine was > 2 mg/dL, and renal replacement therapy (RRT) was initiated. The selected patients were treated with CVVHDF or SLED.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: June 2016
• Est. primary completion date: June 2009
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• The inclusion criteria were

1. AKI requiring RRT

2. Hemodynamic instability defined by systolic blood pressure = 90 mmHg and/or diastolic blood pressure = 60 mmHg

3. Patients requiring initiation to vasopressor support

Exclusion Criteria:

• Patients with pre-existing chronic kidney disease ( eGFR less than 30 mLmin/1.73m2) were excluded

Related Conditions & MeSH terms

• Acute Kidney Injury
• Wounds and Injuries

Intervention

Procedure:
• Slow efficiency dialysis
Slow dialysis 4 times weekly 8 hours CVVHDF predilution mode

Locations

Country	Name	City	State
Thailand	Renal Unit, BMA Medical College and Vajira Hospital	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Bangkok Metropolitan Administration Medical College and Vajira Hospital

Country where clinical trial is conducted

Thailand, 

References & Publications (1)

Manns B, Doig CJ, Lee H, Dean S, Tonelli M, Johnson D, Donaldson C. Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med. 2003 Feb;31(2):449-55. doi: 10.1097/01.CCM. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Adverse events during treatment	Number of patients with catheter infection	30 days
Primary	All-cause mortality	ll-cause mortality at 30 days following RRT initiation	30 day
Secondary	Numbers of patients with abnormal laboratory values	Renal function impairment	30 days
Secondary	ICU stay	Total days in ICU	30 days