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NCT02423642 Clinical Trial

Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

Acute Kidney Injury Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02423642
Other study ID # IRB.136/56
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 2013
Est. completion date November 2014

Study information
Verified date March 2021
Source Chulalongkorn University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date November 2014
Est. primary completion date November 2014
Accepts healthy volunteers No
Gender All
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria: - Systemic inflammatory response syndrome; SIRS > or = 2 meets definition - Patients with acute kidney injury in the intensive care ward. - Requiring continuous renal replacement therapy. Exclusion Criteria: - Pregnancy - Cirrhosis - End stage renal disease - HIV infection - Serum creatinine in male > 2 mg/dl and female > 1.5 mg/dl - Bleeding

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Continuous renal replacement therapy with regional citrate anticoagulation
CRRT with anticoagulant : regional citrate anticoagulation Filter : AQUAMAX™ (Edwards Lifesciences)
• Continuous renal replacement therapy with no anticoagulation or heparin
CRRT with any anticoagulant : no anticoagulation or heparin Filter : AQUAMAX™ (Edwards Lifesciences)

Locations
Country Name City State
Thailand Sasipha Tachaboon Bangkok Pathumwan

Sponsors (1)
Lead Sponsor Collaborator
Chulalongkorn University

Country where clinical trial is conducted

Thailand, 

Outcome
Type Measure Description Time frame Safety issue
Primary Functions of inflammatory cells CD11b expression on PMN and HLA-DR expression on monocyte 24 hours
Primary Regulation of inflammatory reactions and and opsonization in microorganisms C3a and C5a 24 hours
Primary Activity of acute phase protein during acute inflammation PAI-1 24 hours
Secondary survival rate 28 days
Secondary length of ICU stay 28 days
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