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Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients — GDT-AKIN  

Acute Kidney Injury Clinical Trial

Official title:
Goal Directed Therapy in the Early Phase of Acute Kidney Injury in Critical Ill Patients

Clinical Trial Summary

Acute kidney injury (AKI) is a frequent complication in critically ill patients admitted to intensive care unit (ICU) and it is associated with increased morbimortality.

There is evidence that perioperative hemodynamic optimization decreases the incidence of AKI in the post operative phase in high-risk patients. We aimed to evaluate if the use of a goal-directed therapy to increase oxygen delivery in the early phase of acute kidney injury can decrease the prevalence of patients with acute renal failure.

Clinical Trial Description

Randomized, controlled, multicenter study.The intervention group was monitored with Flo Trac/Vigileo and optimized with fluid challenges, dobutamine and blood transfusion, if necessary, to maintain a IDO² ≥600ml/min/m² during 8h. The control group was treated according to the discretion of the attending physician. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02414906
Study type Interventional
Source Barretos Cancer Hospital
Contact
Status Completed
Phase Phase 2
Start date June 2010
Completion date December 2014
View Details
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