Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

Clinical Trial Description

NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01554345
Study type	Interventional
Source	Tehran University of Medical Sciences
Contact	Mahmoodreza Torkaman, resident
Phone	0098 917 105 0954
Email	MRZTORKAMAN@yahoo.com
Status	Recruiting
Phase	Phase 2
Start date	June 2011

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