Acute Kidney Failure Clinical Trial
Official title:
The Effect of Regional Citrate Anti-coagulation on the Coagulation System in Critically Ill Patients Receiving Continuous Renal Replacement Therapy for Acute Kidney Injury - an Observational Cohort Study
The aim of this study is to evaluate the effect of regional citrate anti-coagulation on different pathways of the coagulation system in critically ill patients with acute kidney injury. This will form the basis for future studies where the investigators plan to focus on patients with premature circuit clotting despite optimal post-filtrate ionised calcium parameters.
Purpose of clinical trial:
To evaluate the effect of regional citrate anti-coagulation on different pathways of the
coagulation system in critically ill patients with acute kidney injury.
Patient population:
critically ill patients with acute kidney injury requiring citrate-based continuous renal
replacement therapy (CRRT)
Primary objective:
Changes from baseline in a number of measures of coagulability (platelet count; Prothrombin
Time; Activated Partial Thromboplastin Time ratio; fibrinogen; d-dimers; Thrombin generation
assay; Clot lysis; platelet function analysis 100) in both the blood within the patient's
systemic circulation and the CRRT circuit over the course of 72 hours of regional
anticoagulation with citrate.
Number of Subjects/Patients:
12 patients with complete data.
Trial Design:
Prospective non-interventional study.
Endpoints:
Change from baseline in a number of measures of coagulability.
Main Inclusion Criteria:
Adult intensive care patients undergoing CRRT with citrate regional anti-coagulation for AKI.
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