Acute Kidney Failure Clinical Trial
Official title:
Evaluation of Immune Function in Patients With Acute Kidney Injury
Verified date | January 2024 |
Source | Guy's and St Thomas' NHS Foundation Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The immune response to kidney damage during acute kidney injury (AKI) is an important contributor to the prolonged lack of renal function and progression of kidney injury. Most data related to intrarenal and interorgan pathways in AKI stem from animal research with sometimes conflicting results. Accurate evaluation of these processes in humans and identification of early diagnostic tools are critical for the development of strategies to prevent and attenuate AKI-related morbidity and mortality in patients. The aim of this study is to evaluate immune function and miRNA expression in hospitalised patients with and without AKI.
Status | Active, not recruiting |
Enrollment | 120 |
Est. completion date | December 1, 2026 |
Est. primary completion date | August 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult patients (= 18 years) admitted to the hospital (incl ICU) with one of the following: 1. postoperative AKI II or III and systemic inflammation without sepsis 2. systemic inflammation and normal renal function 3. AKI II or III without systemic inflammation 4. post-surgery with normal renal function and without SIRS or an infection Exclusion Criteria: - Renal transplant patients - Patients on immunosuppressive drugs (except steroids) - Patients with haematological malignancy - Jehovah's witness |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Guy's & St Thomas Foundation Hospital | London |
Lead Sponsor | Collaborator |
---|---|
Guy's and St Thomas' NHS Foundation Trust | King's College London |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Phenotypic characteristics and function of leukocytes | 7 days | ||
Secondary | Differences in phenotypic characterisation and function of neutrophils between AKI stage II and III. | 7 days | ||
Secondary | Differences in phenotypic characterisation and function of neutrophils between AKI and no AKI | 7 days | ||
Secondary | Differences in cytokine profiles between AKI + SIRS and AKI without SIRS | 7 days | ||
Secondary | Differences in cytokine profiles between SIRS + AKI and SIRS without AKI | 7 days | ||
Secondary | Correlation between microRNA levels in patients with AKI and renal recovery | Correlation between microRNA levels in patients with AKI and patient outcome Differences in cytokine profiles between AKI patients without systemic inflammation and patients without AKI and without systemic inflammation / infection. | 7 days | |
Secondary | Correlation between microRNA levels in patients with AKI and patient outcome | Differences in cytokine profiles between AKI patients without systemic inflammation and patients without AKI and without systemic inflammation / infection. | 7 days | |
Secondary | Differences in cytokine profiles between AKI patients without SIRS and patients without AKI and without SIRS | 7 days |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT00760591 -
Change of Neutrophil Gelatinase-Associated Lipocalin(NGAL) Following Sodium Phosphate Bowel Preparation(Pilot Study)
|
N/A | |
Completed |
NCT00890214 -
Prostacyclin's Effect on Platelet Responsiveness
|
Phase 4 | |
Active, not recruiting |
NCT03675906 -
The Relationship Between Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria
|
||
Recruiting |
NCT04334707 -
Kidney Precision Medicine Project
|
||
Active, not recruiting |
NCT04079829 -
Postoperative Respiratory Abnormalities
|
||
Recruiting |
NCT00424320 -
Clinical Trial of Sodium Bicarbonate to Prevent Contrast-Induced Nephropathy
|
Phase 3 | |
Completed |
NCT00472563 -
Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
|
Phase 2/Phase 3 | |
Withdrawn |
NCT03846258 -
High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
|
Phase 4 | |
Completed |
NCT06358365 -
Enhancing Fluid Transfer Through the Skin, by Increased Sweat Rate, on Hemodialysis Patients
|
N/A | |
Completed |
NCT00252200 -
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
|
Phase 1/Phase 2 | |
Completed |
NCT04190979 -
Clinical Application of the Medyria TrackCath System in Endovascular Repair of Abdominal Aortic Aneurysms (AAA)
|
N/A | |
Completed |
NCT04917497 -
Levosimendan Infusion in Critically Ill Patients With Cardiogenic Shock
|
||
Recruiting |
NCT05309291 -
Theranova Randomized, Controlled, Trial (RCT) in China
|
N/A | |
Completed |
NCT02486614 -
Effect of Citrate on the Coagulation System in Patients Receiving CRRT
|
||
Active, not recruiting |
NCT05384899 -
Kidney Precision Medicine Project (KPMP) - COVID-19 Protocol
|
||
Completed |
NCT06190522 -
Diagnosis of Acute Obstructive Renal Failure by Clinical Ultrasound Performed by the Emergency Physician.
|
||
Recruiting |
NCT04221932 -
Implementation of CRRT KPI Reports to Standardize and Improve the Quality of CRRT Delivery in Alberta "QUALITY CRRT"
|
||
Active, not recruiting |
NCT01122225 -
Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury
|
N/A | |
Completed |
NCT00529139 -
Hannover Dialysis Outcome Study
|
Phase 4 | |
Recruiting |
NCT04445779 -
Q10 Preloading Before Cardiac Surgery for Kidney Failure Reduction
|
N/A |