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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT02470507
Other study ID # CSP88220
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date June 2013
Est. completion date December 1, 2026

Study information

Verified date January 2024
Source Guy's and St Thomas' NHS Foundation Trust
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The immune response to kidney damage during acute kidney injury (AKI) is an important contributor to the prolonged lack of renal function and progression of kidney injury. Most data related to intrarenal and interorgan pathways in AKI stem from animal research with sometimes conflicting results. Accurate evaluation of these processes in humans and identification of early diagnostic tools are critical for the development of strategies to prevent and attenuate AKI-related morbidity and mortality in patients. The aim of this study is to evaluate immune function and miRNA expression in hospitalised patients with and without AKI.


Description:

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Study Design


Intervention

Other:
AKI
development of immune dysregulation and rise in inflammatory markers and activation of immune cells

Locations

Country Name City State
United Kingdom Guy's & St Thomas Foundation Hospital London

Sponsors (2)

Lead Sponsor Collaborator
Guy's and St Thomas' NHS Foundation Trust King's College London

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Phenotypic characteristics and function of leukocytes 7 days
Secondary Differences in phenotypic characterisation and function of neutrophils between AKI stage II and III. 7 days
Secondary Differences in phenotypic characterisation and function of neutrophils between AKI and no AKI 7 days
Secondary Differences in cytokine profiles between AKI + SIRS and AKI without SIRS 7 days
Secondary Differences in cytokine profiles between SIRS + AKI and SIRS without AKI 7 days
Secondary Correlation between microRNA levels in patients with AKI and renal recovery Correlation between microRNA levels in patients with AKI and patient outcome Differences in cytokine profiles between AKI patients without systemic inflammation and patients without AKI and without systemic inflammation / infection. 7 days
Secondary Correlation between microRNA levels in patients with AKI and patient outcome Differences in cytokine profiles between AKI patients without systemic inflammation and patients without AKI and without systemic inflammation / infection. 7 days
Secondary Differences in cytokine profiles between AKI patients without SIRS and patients without AKI and without SIRS 7 days
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