Optimizing the Management of Acute Diarrhoeal Disease

Status Completed

Clinical Trial Summary

Many children admitted to hospital in Botswana without bloody diarrhoea are presumed to have viral gastroenteritis and so not treated with antibiotics - but they may indeed have a treatable cause for their illness. The investigators will conduct a randomized trial to see if rapid testing using novel methods to identify potentially treatable causes of diarrhoea leads to improved outcomes. The investigators will also be randomizing children to Lactobacillus reuteri DSM (daughter strain) 17938 therapy versus placebo (the standard of care) to see if this treatment decreases the duration of diarrhoea. The proposed study is a large multi-centre trial following the previous pilot trial.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02803827
Study type	Interventional
Source	Hamilton Health Sciences Corporation
Contact
Status	Completed
Phase	Phase 3
Start date	June 2016
Completion date	February 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04682860` - Management of Abdominal Pain in Acute Gastroenteritis Patients With Hyoscine Butylbromide	Phase 4
Recruiting	`NCT03851835` - Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis	Phase 3
Completed	`NCT01577043` - Efficacy of Racecadotril in Acute Watery Diarrhea in Children	Phase 4
Completed	`NCT03234777` - Evaluating a Knowledge Translation Tool for Parents	N/A
Not yet recruiting	`NCT02619201` - Antiemetic Efficacy of Ondansetron Versus Metoclopramide	Phase 3
Completed	`NCT02280759` - Efficacy of Gelatin Tannate in Treatment Acute Gastroenteritis in Children.	Phase 1
Completed	`NCT06090708` - Yogurt Probiotic Bacteria on Relieving Young Children Acute Gastroenteritis	N/A
Recruiting	`NCT05270291` - Infectious Etiology of Vomiting in Children With Presumed Acute Gastroenteritis
Completed	`NCT02025452` - Novel Diagnostics and Probiotics to Improve Management of Paediatric Acute Gastroenteritis	Phase 4
Not yet recruiting	`NCT06038305` - Prevalence of Anemia and Growth Assessment in Acute Gastroenteritis
Completed	`NCT02644200` - Gelatin Tannate as Treatment for Acute Childhood Gastroenteritis	Phase 3
Completed	`NCT02174874` - Ondansetron Oral Versus Orally Disintegrating Tablets (ODT)	N/A
Completed	`NCT03539913` - Efficacy and Safety of Probiotics in the Treatment of Acute Gastroenteritis in Children	Phase 4
Recruiting	`NCT06137014` - Fortified Oral Rehydration Therapy for Pediatric Diarrhea	Phase 1/Phase 2
Completed	`NCT04463355` - Video Discharge Instructions for Pediatric Gastroenteritis in an Emergency Department	N/A
Completed	`NCT04555200` - Continuous Enteral Rehydration by Nasogastric Tube With ORS in Children With Acute Gastroenteritis
Completed	`NCT02169817` - Evaluation Of Bacillus Clausii In Treatment Of Acute Diarrhea In Latin American Children	Phase 4
Unknown status	`NCT02177799` - Surveillance Study of Acute Gastroenteritis in Hospitalized Children in Rural Area in Lebanon	N/A
Completed	`NCT01886755` - Efficacy of an Oral Rehydration Solution Containing the Probiotic Lactobacillus Reuteri Protectis and Zinc in Infants With Acute Gastroenteritis	N/A
Completed	`NCT01571856` - Efficacy of Use of Zinc in the Treatment of Acute Diarrhea in Infants	Phase 4