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Acute Disease clinical trials

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NCT ID: NCT04440267 Not yet recruiting - Clinical trials for Acute Leukemia of Ambiguous Lineage

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

Start date: June 20, 2020
Phase: Phase 2
Study type: Interventional

In this prospective, single arm, open label, clinical trial, a total of 50 acute leukemia of ambiguous lineage patients will be enrolled. Patients will receive acute lymphoblastic leukemia (ALL) -based chemotherapy and are permitted to receive allogeneic hematopoietic stem cell transplantation (HSCT) after CR . Otherwise, they will finish the consolidation chemotherapy. Patients with t(9;22) will receive chemotherapy combined with tyrosine kinase inhibitors. The purpose of current study is to evaluate the clinical efficacy of ALL-based chemotherapy,effect of genetic abnormality and minimal residual disease (MRD) on prognosis in patients with acute leukemia of ambiguous lineage.

NCT ID: NCT04033198 Not yet recruiting - Clinical trials for Acute Appendicitis in Elderly

Clinicopathological Aspects of Acute Appendicitis in Patients Above Age of Thirty at Sulaimani Emergency Hospital

Start date: July 2019
Phase:
Study type: Observational

Aims of this study are : - Estimate the incidence of A.A. in patients above age of 30 y in 4 age groups . - Correlate between different clinical aspects and histopathological results. - Determine rate of negative appendectomy in those patients.

NCT ID: NCT03892850 Not yet recruiting - Acute Disease Clinical Trials

Effectiveness and Safety of the Nursing Prescription in Acute Health Problems of Low Complexity

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

Objective: To compare the efficacy/effectiveness of pharmacological nurse prescription with medical prescription in patients attended in a primary care center for minor acute health problems. Scope of the study: Multicenter study, with the participation of 8 primary care centers of Catalonia. Methodology: Randomized blind clinical trial, with experimental group receiving pharmacological nurse prescription and a control group receiving medical prescription. Subjects are individuals who request a same day consultation for minor acute pathologies and meet the selection criteria, with random assignment of 374 subjects, 187 per group. The efficacy/effectiveness of the prescribed treatment will be considered as a no re-attendance during the following 72h and will be completed with the variables: information and knowledge of the treatment, adverse effects, compliance, satisfaction level and resolution of the health problem. The data collection is done 10 days after the visit by an ad-hoc telephone questionnaire of 11 items, previously tested. The analysis is done using the SPSS software version 21.0, obtaining data of descriptive, multivariate and inferential statistics. Implications for practice: To evidence the equivalence of pharmacological nurse prescription with medical prescription for minor acute health problems

NCT ID: NCT03743909 Not yet recruiting - Acute Leukemia Clinical Trials

Expression of Aberrant CD Markers in Acute Leukemia:Retrospective Study in South Egypt Cancer Institute

Start date: January 1, 2019
Phase:
Study type: Observational

- To determine incidence of Expression of aberrant CD markers in acute leukemia in South Egypt . - Correlation between this expression and outcome of the patient.

NCT ID: NCT03599869 Not yet recruiting - Clinical trials for Mixed Phenotype Acute Leukemia

Management of Mixed-Phenotype Acute Leukemia in the East of France

ELABEST
Start date: September 2018
Phase:
Study type: Observational

Clinical presentation and management of Mixed-Phenotype Acute leukemia (MPAL) is heterogeneous. This descriptive observationnal study aims to review MPAL cases in the East of France based on a 10-year multicentre retrospective collection.

NCT ID: NCT03310385 Not yet recruiting - Acute Bronchitis Clinical Trials

Efficacy and Safety of GHX02 in the Treatment of Acute Bronchitis

Start date: March 18, 2019
Phase: Phase 2
Study type: Interventional

This study is a phase 2, multicentre, dose-finding, double-blind, randomized placebo-controlled trial to evaluate the efficacy and safety of two different doses of GHX02, compared with placebo, for acute bronchitis. One-hundred and fifty patients will be included in this trial and randomly assigned to either a high-dose GHX02 group(1920mg/day), standard-dose GHX02 group(960mg/day), or control group(placebo) in a 1:1:1 allocation ratio. Patients will take one of the medications three times a day for 7 days, with 3 visiting days(screening, day0, day7). On the screening day, the Korean Standard Tool of Pattern Identification of Cough and Sputum, a diagnostic system that determines therapy in Traditional Korean Medicine, will be used to allocate patients into three groups of wind-heat, wind-cold or others.

NCT ID: NCT03278145 Not yet recruiting - Clinical trials for Acute Lymphoblastic Leukemia

Dependence Receptors and Leukemia

Start date: November 2017
Phase: N/A
Study type: Observational

Acute leukaemias (AL) are the first cause of cancer in children, with a majority of B acute lymphoblastic leukemia (ALL). Some of the processes causing leukemogenesis are already identified and well characterized in some AL subtypes such as translocation t (12; 21) of good prognosis in ALL. However, translocations are not sufficient to explain all the different processes of leukemogenesis, and other processes such as genetic / epigenetic mutations leading to oncogene activation / inhibition of tumor suppressor genes are the object research. Among the latter, mutations in tumor suppressor genes such as DCC (Deleted in Colorectal Cancer) have recently been identified in solid cancers, such as in hemopathies. This gene was subsequently characterized as encoding a "dependence receptor" specifically binding to its Netrin-1 ligand. Dependence receptors (RDs) are transmembrane receptors that cause cell death in the absence of their ligand. RD decreases tumor progression and overexpression of their ligands is observed in many cancers, such as B lymphomatous hemopathies in adults. Inhibition of the RD-ligand interaction constitutes a new and original therapeutic target in oncology. The aim of this study is to investigate whether RDs, in particular DCC, are expressed in acute leukemia cells at the time of diagnosis or relapse in patients aged 1 to 18 years, and then in these patients at the time of the remission balance. This research will be both qualitative and quantitative.

NCT ID: NCT03267485 Not yet recruiting - Acute Leukemia Clinical Trials

Expression of TET1 Gene in Acute Leukaemia

Start date: November 1, 2017
Phase: N/A
Study type: Observational

The aim of the present study is to detect the expression of TET 1 gene in patients with acute leukemia and its correlation with clinical and pathological criteria of the patients.

NCT ID: NCT02789865 Not yet recruiting - Acute Appendicitis Clinical Trials

Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis

Start date: May 2016
Phase: Phase 2
Study type: Interventional

Endoscopic retrograde appendicitis therapy (ERAT) is a new and minimally invasive method for the diagnosis and treatment of acute appendicitis.After a positive diagnosis of acute appendicitis is established by either colonoscopic direct-vision imaging or fluoroscopic endoscopic retrograde appendicography (ERA) imaging in patients with suspected acute appendicitis, the procedures to relieve the appendiceal lumen obstruction including appendiceal luminal irrigation, appendicolith removal, and stenting for drainage whenever necessary will be carried out. In this multicenter prospective randomized clinical trial, the patients with uncomplicated acute appendicitis will be divided into three groups randomly: ERAT group, antibiotic therapy group and appendectomy group. The primary outcome is duration of abdominal pain. The secondary outcomes include mean hospital stay, mean operative time, duration of fever, duration of leukocytosis, bed time, rate of complication, rate of recurrence and rate of appendectomy during follow-up period of 1 year.

NCT ID: NCT00461201 Not yet recruiting - Acute Disease Clinical Trials

Nurse vs General Practitioner Care for Patients Requesting Same Day Consultations in Primary Care

Start date: January 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the effectiveness of nursing care in relation to usual medical care in adult patients who demand to be visited the same day in Primary Care Teams in Catalonia, as it is suggested in other countries.