Acute Coronary Syndome Clinical Trial
Official title:
a Single Centre Open Pilot Study to Explore if the Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide?
Background
Acute coronary syndrome (ACS) is a term representing all diseases related to reduction in
blood flow to the heart characterised by clot formation over a segment of blood vessel
narrowing. A major constituent of clot are blood cells called platelets and many of the
medications used in ACS target platelet function. Ticagrelor is known to reduce platelet
activity in clot formation by blocking a specific step in the process (P2Y12 receptors). A
recent study has found that the presence of ticagrelor may also reduce clot formation by
significantly enhancing another process involving the molecule nitric oxide (NO). This is of
particular interest if translates into clinical practice, as many patients with heart disease
have abnormal function of their blood vessel lining. This is known to cause a reduction in
available nitric oxide. Does this therefore mean these patients will have a reduced response
to ticagrelor therapy and subsequently be at increased risk of clot formation?
Aims
1. Will ticagrelor increase the anti clot effect of vessel lining produced nitric oxide?
2. Do patients with diabetes or smokers, who have poor function of their vessel lining,
have a reduced response to ticagrelor?
Methods
This is a pilot study in which we propose to look at 64 patients with known disease of their
heart blood vessels, with an equal mix of smokers, diabetics, smoking diabetics and non
smoking non diabetics. We will also recruit ten healthy normal subjects to ensure that our
tests produce the same results as the basic science study mentioned above.
To answer the questions posed we will perform blood tests, primarily looking at platelet
function, and non-invasive blood vessel lining assessment. This will be done before and after
ticagrelor treatment on each participant, enabling statistical comparison.
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