Acute Bronchiolitis Clinical Trial
Official title:
FeNO and Cytokines in RSV and Non RSV Bronchiolitis in Relation to Future Asthma
The purpose of this study is to determine Fractional exhaled Nitric-Oxide (FeNO)levels and blood cytokines during acute bronchiolitis, and to seek for correlation between these markers and future development of asthma.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | |
Est. primary completion date | August 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A to 2 Years |
Eligibility |
Inclusion Criteria: - First episode of shortness of breath - Children in ages 2 weeks to 2 years Exclusion Criteria: - Any chronic disease - Congenital anomalies |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Sourasky Medical Center | Tel-Aviv |
Lead Sponsor | Collaborator |
---|---|
Tel-Aviv Sourasky Medical Center |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Wheezing episode | From recruitment time till the age 4. | No | |
Other | PCR for respiratory viruses | Polymerase chain reaction (PCR) analysis of nasal secretion for: RSV, Influenza A, Influenza B, Pandemic H1N1, Adenovirus, human metapneumovirus (hMPV), Parainfluenza 1-3, Enterovirus, Bocavirus, Rhinovirus, Corona virus-229E, Corona-OC43, Corona-HKU1 and Corona-NL63. | At recruitment | No |
Primary | Physician diagnosed asthma | Modification of The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires | At the age of 4 years | No |
Secondary | Fractional exhaled Nitric Oxide (FENO) level | FeNO level measured by a rapid-response chemiluminescence analyzer (Eco Physics CLD88 NO analyzer, EcoMedics AG,Switzerland). | During acute bronchiolitis, after 2 and 6 months | No |
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