Protocols for Painless Photodynamic Therapy (PDT) of Actinic Keratoses

Status Completed

Clinical Trial Summary

This study is being done to compare a new, continuous illumination regimen of ALA-PDT (Aminolevulinate-Photodynamic Therapy) to a conventional regimen for treatment of actinic keratoses. The hypothesis is that the continuous illumination approach will be less painful, but equally efficacious, as the old regimen.

Clinical Trial Description

This study is being done to compare a modified version of the standard ALA-PDT (Aminolevulinate-Photodynamic Therapy) treatment of actinic keratoses, to a modified version in which light exposure begins immediately after application of the Levulan. We hypothesize that this will yield a therapeutic efficacy equivalent to the standard ALA-PDT regimen, but will cause less pain during the light exposure. The study employs a bilateral design in which the left versus right sides of the treatment area are compared in the exact same patient. There are 3 arms of the study, each having a different time duration of light exposure in the modified regimen to determine which one is most efficacious ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02124733
Study type	Interventional
Source	The Cleveland Clinic
Contact
Status	Completed
Phase	Phase 3
Start date	April 2014
Completion date	December 2018

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See also
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