Actinic Keratosis Clinical Trial
Official title:
Phase III Comparative Study About the Use of 5% 5-fluorouracil Cream Versus Its Utilization as Agent for Sequential Superficial Peeling in the Treatment of Advanced Photoaging
It is well known the efficacy of 5% 5-fluoruracil for multiple and superficial actinic
keratosis (AKs)treatment. Recently its additional benefit for advanced and severe photoaging
while treating Aks was reported.
The aim of this study is to compare the efficacy and safety of the two modalities of 5% 5-FU
use for forearms photoaging.
The use of 5% 5-fluorouracil (5-FU) cream, twice a day, during 3 weeks represents a classic
treatment for multiple and superficial AKs. The main adverse event is the severe skin
irritation leading to interruption of the treatment in some cases. In the last decade a
superficial pulse-peeling using it as agent in sequential applications was described. This
modality of treatment has been demonstrated efficacy and better tolerability.
The improvement of the overall aspect of photodamaged skin is observed while treating
multiple AKs.
There are no comparative study between the two types of 5% 5-FU use. So that is the purpose
of our clinical trial.
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