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NCT05073211 Clinical Trial

St. John's Wort Photodynamic Therapy

Acne Clinical Trial

— SJWPDT  

Official title:
A Randomized Split-face Study of Photodynamic Therapy With St. John's Wort Versus Indole-3-acetic Acid for the Treatment of Acne

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05073211
Other study ID # B-1906547-003
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 1, 2020
Est. completion date September 1, 2021

Study information
Verified date September 2021
Source Seoul National University Bundang Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators aimed to evaluated the efficacy and safety of SJW-PDT compared to indole-3-acetic acid (IAA)-PDT in the treatment of acne. The investigators also investigated the skin rejuvenating effects of SJW-PDT.

Recruitment information / eligibility
Status Completed
Enrollment 31
Est. completion date September 1, 2021
Est. primary completion date April 1, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 25 Years to 60 Years
Eligibility Inclusion Criteria: - patients with mild to moderate facial acne - between 25 and 60 years old Exclusion Criteria: - history of oral retinoid treatment with the past 6 months - history of oral antibiotics, topical acne treatment, or skin rejuvenation treatment such as lasers and chemical peeling within the month before the start of the study

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• PDT
A 630 nm red light and a 520 nm green light of the light-emitting diode (LED) device (Nouvo-GB®) with an intensity of 35 mW/cm2 was simultaneously illuminated for 10 minutes (a total light dose of 21 J/cm2). Participants received a total of four treatments at 1-week intervals and were followed up 1 and 4 weeks after the last treatment.

Locations
Country Name City State
Korea, Republic of Seoul National University Bundang Hospital Seongnam

Sponsors (1)
Lead Sponsor Collaborator
Seoul National University Bundang Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Other erythema index (arbitrary unit) The erythema index (EI) was measured with Mexameter MX 1® (Courage & Khazaka) 1 and 4 weeks after the last treatment
Other skin texture, wrinkles (arbitrary unit) The skin texture and wrinkles were measured with an Antera 3D® camera (Miravex Limited, Dublin, Ireland). 1 and 4 weeks after the last treatment
Primary acne lesions change in the number of acne lesions after the treatment 1 and 4 weeks after the last treatment
Secondary sebum secretion rate (µg/cm2) Sebum secretion rate was measured with Sebumeter SM 815®. 1 and 4 weeks after the last treatment
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