Acne Clinical Trial
— AcneOfficial title:
The Lipid Profile of the Skin Surface in Acne
Verified date | May 2017 |
Source | University of California, Davis |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.
Status | Completed |
Enrollment | 30 |
Est. completion date | July 2015 |
Est. primary completion date | May 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 12 Years to 30 Years |
Eligibility |
Inclusion Criteria: - age 12 to 30 years - have been prescribed tretinoin OR isotretinoin Exclusion Criteria: - those who have taken isotretinoin (systemic) - those who used tretinoin or other topical retinoid within two weeks of starting the study - those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome - those who are pregnant, prisoners, or cognitively impaired - those who do not fit the inclusion criteria |
Country | Name | City | State |
---|---|---|---|
United States | Dermatology Research Area | Davis | California |
United States | UC Davis Department of Dermatology | Sacramento | California |
Lead Sponsor | Collaborator |
---|---|
University of California, Davis |
United States,
Blume U, Verschoore M, Poncet M, Czernielewski J, Orfanos CE, Schaefer H. The vellus hair follicle in acne: hair growth and sebum excretion. Br J Dermatol. 1993 Jul;129(1):23-7. — View Citation
Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997 Jun;36(6):416-8. — View Citation
Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976 May;66(5):319-23. — View Citation
Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989 Apr;69(2):383-416. Review. — View Citation
Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008 Jun;17(6):542-51. doi: 10.1111/j.1600-0625.2008.00725.x. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Skin lipid profile of acne and healthy patients | Compare the skin lipid profile of acne and healthy patients at baseline | baseline visit | |
Secondary | Skin lipid profile of acne patients after treatment | Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment. | at 1 month and 4-5 months of treatment |
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