Acne Clinical Trial
Official title:
A Pilot Study to Evaluate the Efficacy of Low-level Laser Therapy in Reducing Blemishes by Quantifying a Decrease in Signs of Blemishes, Both Non-inflammatory and Inflammatory
The purpose of this study is to determine whether low level laser light therapy is effective in the treatment of acne blemishes.
Acne is a chronic inflammatory disorder plaguing the sebaceous follicle, and debate still
remains over what truly initiates lesion formation. Experts agree that an increase in
androgen production plays a significant role in the onset of acne. Androgens promote the
increase in size of sebaceous glands and stimulate sebum production. The simple act of
sebaceous gland stimulation via androgens could ultimately promote the upregulation of
pro-inflammatory cytokines like tumor necrosis factor-α (TNF-α) and interleukin (IL-1α)
without propionibacteria even being present. The synthesis of IL-α and other
pro-inflammatory cytokines including prostaglandins occurs via the inducible enzyme known as
cyclooxygenase-2 (COX-2). Studies analyzing the pathogenesis of mucositis have identified
COX-2 as an important contributor to the upregulation of pro-inflammatory cytokines and thus
a major contributor to the progression of the disorder itself.
Recent evidence indicates that low-level laser therapy (LLLT) is able to significantly
diminish the expression of COX-2, resulting in the reduction of inflammation. The ability to
modulate the COX-2 pathways via LLLT is believed to inhibit the production of
pro-inflammatory cytokines (i.e. TNF-α and IL- α) present in acne-prone skin.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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