Clinical Trials Logo

Clinical Trial Summary

The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients. The current advice in younger patients is usually to undergo ACL reconstruction. The choice of an ideal graft in children is difficult This study will use a technique involves the use of hamstring tendons from a living donor, where the adult (usually a parent) agrees to donate their hamstring tendons, which are dissected out of them and implanted into the child


Clinical Trial Description

The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients. Following rupture of this ligament, the current advice in younger patients is usually to undergo ACL reconstruction. Different tissue or materials can be used to reconstruct the ligament. In the majority of cases around the world, tendon material taken from somewhere else in the patient is preferred, particularly the hamstring or patellar tendons. The choice of an ideal graft in children is difficult. Patients who have not fully grown have smaller tendons than adults, making them less suitable for use in reconstructive surgery. Another option for children's reconstructions is allograft - tendons taken from another human being. This has most commonly been from organ donation (taking tendons from a recently deceased individual) however the rerupture rate of allograft has been shown to be higher than in autograft (tendons taken from the patient themselves). The higher rate of rerupture may be related to the sterilising and storage processes of the harvested tendons. This study will use a technique used by a leading hospital in Sydney, Australia, that sees and treats a large volume of these patients and has published good outcomes. The technique involves the use of hamstring tendons from a living donor, where the adult (usually a parent) agrees to donate their hamstring tendons, which are dissected out of them and implanted into the child. The technique has the advantage of leaving the child's own tendons intact, and having a larger sized tendon from a parent. Patients & parents will be approached in clinic after MRI confirmation of an ACL rupture. If all inclusion and exclusion criteria have been passed and they consent to participate, screening documents & tests will be completed. The parent will undergo a hamstring tenotomy whilst the child is prepped for ACL reconstruction, then the hamstring donor graft will be inserted in the child patient, using the surgeon's routine fixation devices. All patients will be assessed for skeletal maturity prior to surgery and will be followed up for two years or until skeletal maturity, whichever happens latest. They will follow standard rehabilitation guidelines for paediatric patients at Maidstone & Tunbridge Wells National Health Service Trust (MTW NHS Trust) and be seen at set study intervals for clinical review, subjective and objective assessment. Any adverse events will be reported to the health regulation authority and Human Tissue Licence Authority. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05395767
Study type Interventional
Source Maidstone & Tunbridge Wells NHS Trust
Contact Helen Samuel, MSc
Phone 01892 635488
Email h.sankey@nhs.net
Status Recruiting
Phase N/A
Start date September 15, 2021
Completion date September 2028

See also
  Status Clinical Trial Phase
Withdrawn NCT01433718 - Decreasing Knee Injury Risk Factors With Neuromuscular Training N/A
Withdrawn NCT03670550 - Dynamic ACL Brace: In Vivo Kinematics N/A
Recruiting NCT06430775 - Exploring Prolonged AMR in ACL Reconstructed Patients
Recruiting NCT04586361 - Prospective Analysis of Introperative RegenLab PRP and Hyaluronic Acid in Patients With Knee ACL Tear Phase 4
Active, not recruiting NCT06167343 - Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction N/A
Completed NCT01727739 - Tibial Tunnel Widening in Anterior Cruciate Ligament (ACL) Reconstruction-Comparing Two Bioscrews N/A
Completed NCT03711734 - Acupuncture ACL (Anterior Cruciate Ligament) N/A
Recruiting NCT04137003 - Laval University Rouge et or Post ACL Surgery Program Effectiveness N/A
Completed NCT05876013 - Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon Group
Completed NCT05048420 - THE EFFECT OF RAMP LESION REPAIR ON RETURN TO SPORTS IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION N/A
Recruiting NCT06456268 - VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction N/A
Terminated NCT05878652 - Playmaker 3D Printed Knee Extender N/A
Recruiting NCT05542563 - Mindfulness and ACL Surgery N/A
Completed NCT02913404 - ACL-reconstruction vs ACL-reconstruction With EAT N/A
Recruiting NCT05720949 - Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery Phase 4
Recruiting NCT04753424 - Semitendinosus Graft as Meniscal Transplant
Not yet recruiting NCT04721119 - Comparing Adductor Canal Block and Adductor Canal Block-Local Infiltration Analgesia for Post-operative Pain Management N/A
Recruiting NCT03080402 - Mechanical Perturbation Training for ACL Injury Prevention N/A
Recruiting NCT06194682 - Anterior Cruciate Ligament Study
Enrolling by invitation NCT05161221 - Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction Phase 3