Acid-Base Imbalance Clinical Trial
Official title:
Changes in Acid-base Variables Induced by Acute Variations in Partial Pressure of Carbon Dioxide in Whole Blood and Isolated Plasma of Septic Critically Ill Patients and Healthy Volunteers: an In-vitro Study
Verified date | March 2019 |
Source | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Alterations of acid-base equilibrium are very common in critically ill patients and
understanding their pathophysiology can be important to improve clinical treatment.
The human organism is protected against acid-base disorders by several compensatory
mechanisms that minimize pH variations in case of blood variations in carbon dioxide content.
The aim of the present study is to quantify the buffer power, i.e. the capacity to limit pH
variations in response to carbon dioxide changes, in critically ill septic patients and
compare these results with data collected from healthy volunteers.
Status | Completed |
Enrollment | 36 |
Est. completion date | February 20, 2019 |
Est. primary completion date | February 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Septic patients and healthy volunteers Exclusion Criteria: - age < 18 years and pregnancy |
Country | Name | City | State |
---|---|---|---|
Italy | IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico | Milan |
Lead Sponsor | Collaborator |
---|---|
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Non-carbonic buffer power | Non-carbonic buffer power (beta) of whole blood and isolated plasma [expressed as variations in bicarbonate concentration divided by variations in pH). | 1 day | |
Secondary | Strong Ion Difference variations induced by carbon dioxide | Variations in Strong Ion Difference of whole blood and plasma [expressed in milliequivalents per Liter], induced by acute in vitro changes of carbon dioxide | 1 day | |
Secondary | Bicarbonate Variations induced by carbon dioxide | Variations in bicarbonate concentration of whole blood and plasma [expressed in milliequivalents per Liter], induced by acute in vitro changes of carbon dioxide | 1 day | |
Secondary | Oxidized albumin | Oxidized albumin [expressed as percentage of total albumin concentration] | 1 day | |
Secondary | Correlation between hematocrit values and Strong Ion Difference variations | Correlation between hematocrit [expressed as percentage] values and Strong Ion Difference variations [expressed in mEq/L] induced by acute in vitro changes of Carbon Dioxide. Acute variations in partial pressure of carbon dioxide cause changes in Strong Ion Difference. The hypothesis is that the magnitude of Strong Ion Difference variations correlate to the hematocrit, being the red blood cell the major source of electrolytes. The higher the hematocrit, the higher the possible change in Strong Ion Difference induced by acute variations in partial pressure of carbon dioxide. |
1 day |
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